A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes.For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), Cdc48/p97 pulls polyubiquitinated, misfolded proteins out of the ER and
The purpose of this paper is to ponder the reception of the Letter to the Galatians in Abrasives an aural setting.How did the first recipients react, what can we expect that they remembered after having listened to the letter? Are there structural elements in the letter that would have aided the aural reception of the letter? In four readings, the
Mechanical energy fluctuation of the segments of lower limbs during walking has not been fully investigated.It was hypothesized that the segments may work needles as a pendulum, i.e.the kinetic and potential energies exchanged out of phase.This study aimed to investigate energy changes and recovery during gait in hip replacement patients.The gait d
Organizational identity is always somewhat socially co-authored.The social-media context provides an opportunity to interrogate the extent of this co-authoring in an interaction-heavy and difficult to control environment.This article presents a typology of online communities that co-author organizational identity through confirming and disconfirmin
Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial illness that affects many body systems including the immune, nervous, endocrine, cardiovascular, and urinary systems.There is currently no universal diagnostic marker or targeted treatment for ME/CFS.Urine is a non-invasive sample that provides bioma